Clemens Steegborn : rechercher sur Z-Library

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1

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

Li, Jun, Bonkowski, Michael S., Moniot, Sébastien, Zhang, Dapeng, Hubbard, Basil P., Ling, Alvin J. Y., Rajman, Luis A., Qin, Bo, Lou, Zhenkun, Gorbunova, Vera, Aravind, L., Steegborn, Clemens, Sincla

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 929 KB

english, 2017

2

Sirtuin activators and inhibitors: Promises, achievements, and challenges

Dai, Han, Sinclair, David A., Ellis, James L., Steegborn, Clemens

Journal:

Pharmacology & Therapeutics

Année:

2018

Langue:

english

Fichier:

PDF, 6.47 MB

english, 2018

3

Crystal structure of the putative adapter protein MTH1859

Hong Ye, Tzu-Chao Chen, Xiaohui Xu, Micha Pennycooke, Hao Wu, Clemens Steegborn

Journal:

Journal of Structural Biology

Année:

2004

Langue:

english

Fichier:

PDF, 649 KB

english, 2004

4

New assays and approaches for discovery and design of Sirtuin modulators

Schutkowski, Mike, Fischer, Frank, Roessler, Claudia, Steegborn, Clemens

Journal:

Expert Opinion on Drug Discovery

Année:

2014

Langue:

english

Fichier:

PDF, 807 KB

english, 2014

5

Using mitochondrial sirtuins as drug targets: disease implications and available compounds

Gertz, Melanie, Steegborn, Clemens

Journal:

Cellular and Molecular Life Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 2.46 MB

english, 2016

6

Sirtuin- cAMP crosstalk in metabolic diseases: nucleus versus mitochondria

Teodoro, João S., Amorim, João A., Silva, Rui, Rolo, Anabela P., Steegborn, Clemens, Sinclair, David A., Palmeira, Carlos M.

Journal:

Free Radical Biology and Medicine

Année:

2018

Langue:

english

Fichier:

PDF, 47 KB

english, 2018

7

Structure and Mechanism of Iodothyronine Deiodinases – What We Know, What We Don’t Know, and What Would Be Nice to Know

Steegborn, Clemens, Schweizer, Ulrich

Journal:

Experimental and Clinical Endocrinology & Diabetes

Année:

2019

Langue:

english

Fichier:

PDF, 261 KB

english, 2019

8

Structure and Mechanism of Iodothyronine Deiodinases – What We Know, What We Don’t Know, and What Would Be Nice to Know

Steegborn, Clemens, Schweizer, Ulrich

Journal:

Experimental and Clinical Endocrinology & Diabetes

Année:

2019

Fichier:

PDF, 261 KB

2019

9

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

Teodoro, JoÃ£o S., Amorim, JoÃ£o A., Machado, Ivo F., Castela, Ana C., Steegborn, Clemens, Sinclair, David A., Rolo, Anabela P., Palmeira, Carlos M.

Journal:

International Journal of Molecular Sciences

Année:

2020

Fichier:

PDF, 1.92 MB

2020

10

Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin

You, Weijie, Steegborn, Clemens

Journal:

ACS Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 2.11 MB

2020

11

Function and regulation of the mitochondrial Sirtuin isoform Sirt5 in Mammalia

Melanie Gertz, Clemens Steegborn

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2010

Langue:

english

Fichier:

PDF, 829 KB

english, 2010

12

Construction and characterization of the direct piezoelectric immunosensor for atrazine operating in solution

Clemens Steegborn, Petr Skládal

Journal:

Biosensors and Bioelectronics

Année:

1997

Langue:

english

Fichier:

PDF, 932 KB

english, 1997

13

Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal β-carbonic anhydrase from Candida albicans with sulfonamides

Alessio Innocenti, Rebecca A. Hall, Christine Schlicker, Andrea Scozzafava, Clemens Steegborn, Fritz A. Mühlschlegel, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 396 KB

english, 2009

14

Carbonic anhydrase inhibitors: Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions

Alessio Innocenti, Fritz A. Mühlschlegel, Rebecca A. Hall, Clemens Steegborn, Andrea Scozzafava, Claudiu T. Supuran

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 181 KB

english, 2008

15

A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors

Valérie Schreiber, Clemens Steegborn, Tim Clausen, Winfried Boos, Evelyne Richet

Journal:

Molecular Microbiology

Année:

2000

Langue:

english

Fichier:

PDF, 588 KB

english, 2000

16

Structural and mechanistic insights into cGMP signaling

Annika Rauch, Michael Russwurm, Christine Schlicker, Martina Leipelt, Clemens Steegborn

Journal:

BMC Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 204 KB

english, 2009

17

Crystal structure of the GAF-B domain from human phosphodiesterase 5

Michael Russwurm, Christine Schlicker, Michael Weyand, Doris Koesling, Clemens Steegborn

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2011

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2011

18

Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment

Steegborn, Clemens, Litvin, Tatiana N, Levin, Lonny R, Buck, Jochen, Wu, Hao

Journal:

Nature Structural and Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 602 KB

english, 2004

19

X-ray structure of MalY from Escherichia coli: a pyridoxal 5′-phosphate-dependent enzyme acting as a modulator in mal gene expression

Clausen, Tim, Schlegel, Anja, Peist, Ralf, Schneider, Eva, Steegborn, Clemens, Chang, Yuh-Shin, Haase, Andrea, Bourenkov, Gleb P., Bartunik, Hans D., Boos, Winfried

Journal:

The EMBO Journal

Année:

2000

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2000

20

Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets

Mahadevan Lakshminarasimhan, Clemens Steegborn

Journal:

Experimental Gerontology

Année:

2011

Langue:

english

Fichier:

PDF, 216 KB

english, 2011

21

Crystal Structure of Transcription Factor MalT Domain III: A Novel Helix Repeat Fold Implicated in Regulated Oligomerization

Clemens Steegborn, Olivier Danot, Robert Huber, Tim Clausen

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 440 KB

english, 2001

22

A protein folding intermediate of ribonuclease T1 characterized at high resolution by 1D and 2D real-time NMR spectroscopy

Jochen Balbach, Clemens Steegborn, Thomas Schindler, Franz X. Schmid

Journal:

Journal of Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 439 KB

english, 1999

23

The crystal structure of cystathionine γ-synthase from Nicotiana tabacum reveals its substrate and reaction specificity

Clemens Steegborn, Albrecht Messerschmidt, Bernd Laber, Wolfgang Streber, Robert Huber, Tim Clausen

Journal:

Journal of Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 1005 KB

english, 1999

24

Crystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor

Clemens Steegborn, Bernd Laber, Albrecht Messerschmidt, Robert Huber, Tim Clausen

Journal:

Journal of Molecular Biology

Année:

2001

Langue:

english

Fichier:

PDF, 669 KB

english, 2001

25

Structural rearrangements on HIV-1 Tat (32–72) TAR complex formation

Armin U Metzger, Thomas Schindler, Dieter Willbold, Margot Kraft, Clemens Steegborn, Andrea Volkmann, Rainer W Frank, Paul Rösch

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 419 KB

english, 1996

26

Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems

Margarita Kamenetsky, Sabine Middelhaufe, Erin M. Bank, Lonny R. Levin, Jochen Buck, Clemens Steegborn

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2006

27

Mapping the ADF/Cofilin Binding Site on Monomeric Actin by Competitive Cross-linking and Peptide Array: Evidence for a Second Binding Site on Monomeric Actin

Hans Georg Mannherz, Edda Ballweber, Marco Galla, Sylvie Villard, Claude Granier, Clemens Steegborn, Anja Schmidtmann, Kornelia Jaquet, Brian Pope, Alan G. Weeds

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 1.56 MB

english, 2007

28

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

Christine Schlicker, Melanie Gertz, Panagiotis Papatheodorou, Barbara Kachholz, Christian F.W. Becker, Clemens Steegborn

Journal:

Journal of Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 941 KB

english, 2008

29

Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

Christine Schlicker, Rebecca A. Hall, Daniela Vullo, Sabine Middelhaufe, Melanie Gertz, Claudiu T. Supuran, Fritz A. Mühlschlegel, Clemens Steegborn

Journal:

Journal of Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2009

30

Crystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosa

Hüsnü Topal, Nanette B. Fulcher, Jacob Bitterman, Eric Salazar, Jochen Buck, Lonny R. Levin, Martin J. Cann, Matthew C. Wolfgang, Clemens Steegborn

Journal:

Journal of Molecular Biology

Année:

2012

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2012

31

Corrigendum to “Crystal structure of the putative adapter protein MTH1859” [J. Struct. Biol. 148 (2004) 251–256]

Hong Ye, Tzu-Shao Chen, Xiaohui Xu, Micha Pennycooke, Hao Wu, Clemens Steegborn

Journal:

Journal of Structural Biology

Année:

2005

Langue:

english

Fichier:

PDF, 67 KB

english, 2005

32

Crystal Structure of the Human CCA-adding Enzyme: Insights into Template-independent Polymerization

Martin A Augustin, Andreas S Reichert, Heike Betat, Robert Huber, Mario Mörl, Clemens Steegborn

Journal:

Journal of Molecular Biology

Année:

2003

Langue:

english

Fichier:

PDF, 2.13 MB

english, 2003

33

Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency

Sally P. Stabler, Clemens Steegborn, Markus C. Wahl, Jana Oliveriusova, Jan P. Kraus, Robert H. Allen, Conrad Wagner, S.Harvey Mudd

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 108 KB

english, 2002

34

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074

Suenkel, Benjamin, Fischer, Frank, Steegborn, Clemens

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 501 KB

english, 2013

35

Crystal structure analysis of human Sirt2 and its ADP-ribose complex

Moniot, Sébastien, Schutkowski, Mike, Steegborn, Clemens

Journal:

Journal of Structural Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2013

36

Structure-Based Development of Novel Adenylyl Cyclase Inhibitors

Schlicker, Christine, Rauch, Annika, Hess, Ken C., Kachholz, Barbara, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2008

37

Crystal Structures of Sirt3 Complexes with 4′-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism

Nguyen, Giang Thi Tuyet, Gertz, Melanie, Steegborn, Clemens

Journal:

Chemistry & Biology

Année:

2013

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2013

38

The Lifespan-Regulator p66Shc in Mitochondria: Redox Enzyme or Redox Sensor?

Gertz, Melanie, Steegborn, Clemens

Journal:

Antioxidants & Redox Signaling

Année:

2010

Langue:

english

Fichier:

PDF, 464 KB

english, 2010

39

Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD + and SRT1720: binding details and inhibition mechanism

Nguyen, Giang Thi Tuyet, Schaefer, Susanne, Gertz, Melanie, Weyand, Michael, Steegborn, Clemens

Journal:

Acta Crystallographica Section D Biological Crystallography

Année:

2013

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2013

40

Cooperativity of a Protein Folding Reaction Probed at Multiple Chain Positions by Real-Time 2D NMR Spectroscopy †

Steegborn, Clemens, Schneider-Hassloff, Henriette, Zeeb, Markus, Balbach, Jochen

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 194 KB

english, 2000

41

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors

Roessler, Claudia, Nowak, Theresa, Pannek, Martin, Gertz, Melanie, Nguyen, Giang T. T., Scharfe, Michael, Born, Ilona, Sippl, Wolfgang, Steegborn, Clemens, Schutkowski, Mike

Journal:

Angewandte Chemie International Edition

Année:

2014

Langue:

english

Fichier:

PDF, 559 KB

english, 2014

42

Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

Steegborn, Clemens

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2014

Langue:

english

Fichier:

PDF, 2.04 MB

english, 2014

43

Human Metastasis Regulator Protein H-Prune is a Short-Chain Exopolyphosphatase †

Tammenkoski, Marko, Koivula, Katja, Cusanelli, Emilio, Zollo, Massimo, Steegborn, Clemens, Baykov, Alexander A., Lahti, Reijo

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 2.15 MB

english, 2008

44

Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes - implications for cyclase catalysis and evolution

Kleinboelting, Silke, van den Heuvel, Joop, Steegborn, Clemens

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2014

45

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors

Roessler, Claudia, Nowak, Theresa, Pannek, Martin, Gertz, Melanie, Nguyen, Giang T. T., Scharfe, Michael, Born, Ilona, Sippl, Wolfgang, Steegborn, Clemens, Schutkowski, Mike

Journal:

Angewandte Chemie

Année:

2014

Langue:

english

Fichier:

PDF, 552 KB

english, 2014

46

SIRT5 regulation of ammonia-induced autophagy and mitophagy

Polletta, Lucia, Vernucci, Enza, Carnevale, Ilaria, Arcangeli, Tania, Rotili, Dante, Palmerio, Silvia, Steegborn, Clemens, Nowak, Theresa, Schutkowski, Mike, Pellegrini, Laura, Sansone, Luigi, Villano

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 6.10 MB

english, 2015

47

A Universal Stress Protein (USP) in Mycobacteria Binds cAMP

Banerjee, Arka, Adolph, Ramona S., Gopalakrishnapai, Jayashree, Kleinboelting, Silke, Emmerich, Christiane, Steegborn, Clemens, Visweswariah, Sandhya S.

Journal:

Journal of Biological Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 3.75 MB

english, 2015

48

Cloning, Purification and Characterisation of Cystathionine γ-Synthase from Nicotiana tabacum

Clausen, Tim, Wahl, Markus C., Clausen, Tim, Wahl, Markus C., Fuhrmann, Jens C., Laber, Bernd, Streber, Wolfgang, Steegborn, Clemens

Journal:

Biological Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 589 KB

english, 1999

49

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase

Kleinboelting, Silke, van den Heuvel, Joop, Kambach, Christian, Weyand, Michael, Leipelt, Martina, Steegborn, Clemens

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2014

Langue:

english

Fichier:

PDF, 203 KB

english, 2014

50

Crystallization and preliminary X-ray diffraction analysis of proximal thread matrix protein 1 (PTMP1) from Mytilus galloprovincialis

Suhre, Michael H., Scheibel, Thomas, Steegborn, Clemens, Gertz, Melanie

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2014

Langue:

english

Fichier:

PDF, 289 KB

english, 2014